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. 2015 Mar 21;9:16. doi: 10.1186/s12918-015-0157-z

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© Huang et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Effects of promoter leakage on the time-dependent number of gene product molecules, where the leakage rate is set as either λ ₀ = 0 (A, B) or λ ₀ = 10 (D, E). (A and D) no feedback, where the parameter values are the same as those used in Figure 3(A); (B and E) negative feedback, where the parameter values are the same as those used in Figure 3(B); (C and F) positive feedback, where the leakage rate λ ₁ is set as 10 for (F) or as 0 for (C), and the other parameter values are the same as those used in Figure 3(C).