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. 2015 Mar 11;17(1):36. doi: 10.1186/s13058-015-0544-9

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© Zhou et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Identification of metastasis-specific lectin binding to TNBC cells. (a) Schematic of the probing of fluorescently labeled cells on the lectin microarray. (b) Layout of the lectin microarray containing 91 lectins. (c) Representative lectin microarray binding patterns of the six TNBC cell lines. (d) Four lectins exhibited different extents of binding to the six different TNBC cell lines. The indicated intensities are represented as the mean values ± standard deviation (SD), n = 4. (e) Clustered heat map of the lectin cell-binding profiles. This map was generated and clustered according to the lectin-binding pattern and mean intensity. The order of the cells in this map closely matches their order of metastatic capacity. TNBC, triple-negative breast cancer.