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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Drugs. 2015 Apr;75(5):445–454. doi: 10.1007/s40265-015-0373-2

Table 1. Measures of Retention and Medication Adherence.

Measures Description

Retention [48, 50, 51]

Missed Visits Number of “no shows” within an observation period

Appointment Adherence Proportion of completed visits (numerator) out of all scheduled visits (denominator) within an observation period

Visit Constancy Proportion of time intervals (usually 3-6 months) with ≥ 1 completed visit within an observation period.

Gaps in Care Time interval (usually months) between completed visits

Hybrid Measures (Visit Constancy and Gaps in Care)
 Institute of Medicine (IOM) Core Indicator Proportion of patients with ≥ 2 visits separated by ≥ 90 days within a 12-month interval
 U.S. Department of Health and Human Services (HHS) Core Indicator Proportion of patients with ≥ 1 visit within each 6-month time period over 24 months, with ≥ 60 days between the first visit in one 6-month time period and the last visit in the subsequent 6-month time period

Adherence

Patient Self-Report Personal estimates of adherence over 1 month using validated questionnaires such as the Visual Analog Scale or the Swiss HIV Cohort Study Adherence Questionnaire

Pharmacy Refill data Dates on which medications were dispensed. Refills that aren't obtained in a timely fashion suggest missed doses, which allow the refill to last longer than it should.

Pill Counting Number of remaining doses of medications, representing the number of missed doses

Directly Administered ART (DAART) Direct observation of patient taking the medication dose

Electronic Drug Monitor (EDM) Pill bottles with a computer chip embedded in the cap that records the time and duration of each opening

Biological Samples Plasma concentrations of medications