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. Author manuscript; available in PMC: 2015 Apr 3.
Published in final edited form as: Nat Rev Mol Cell Biol. 2014 Feb;15(2):122–133. doi: 10.1038/nrm3741

Figure 5. The ATPase arrangements in different conditions.

Figure 5

A cartoon representation of the arrangement of the six ATPases of the proteasome and the aromatic-hydrophobic-glycine loop (black loop from each ATPase structure) for each of the conditions in which proteasome structures were determined. Each ATPase is represented with its large and small domain and in a different color. The spiraled arrangement of the AAA+ domains is obtained in both the substrate-free and ATPγS conditions, though the subunits rearrange in the ATPγS condition, so that now Rpt5 “bridges” the spiral. In the substrate-bound condition, the ATPase domains rearrange to a level plane, but the aromatic-hydrophobic-glycine loops are still arranged in a spiral due to the different tiltings of the ATPase domains. The figure is adapted from Beckwith et al. 2013139.