Table 2.
Numerical distribution of ligand/VEGFR-1 correlations in tumor cells of CC tissue
| VEGFR-1 | VEGF | p | PlGF | p | VEGF-B | p | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| + | - | (r) | + | - | (r) | + | - | (r) | ||
| Tumor center | ||||||||||
| CC | + | 68 | 8 | 0.0001 | 66 | 10 | 0.007 | 23 | 56 | NS 0.4 |
| - | 3 | 7 | (0.5) | 4 | 5 | (0.3) | 1 | 6 | (0.1) | |
| N0/M0 | + | 32 | 4 | 0.009 | 31 | 5 | NS 0.7 | 6 | 30 | NS 0.7 |
| - | 0 | 1 | (0.4) | 1 | 0 | (0.07) | 0 | 1 | (0.07) | |
| N+ | + | 16 | 3 | 0.04 | 17 | 3 | 0.009 | 7 | 15 | NS 0.4 |
| - | 2 | 3 | (0.4) | 1 | 3 | (0.5) | 0 | 2 | (0.1) | |
| M+ | + | 20 | 1 | 0.0001 | 18 | 2 | 0.04 | 10 | 11 | NS 0.6 |
| - | 1 | 3 | (0.7) | 2 | 2 | (0.4) | 1 | 3 | (0.1) | |
| Tumor budding | ||||||||||
| CC | + | 59 | 10 | NS 0.4 | 60 | 7 | 0.02 | 21 | 47 | NS 0.6 |
| - | 2 | 1 | (0.01) | 2 | 3 | (0. 4) | 1 | 4 | (0.05) | |
| N0/M0 | + | 24 | 3 | 0.01 | 24 | 3 | NS 0.7 | 7 | 20 | NS 0.6 |
| - | 0 | 1 | (0.5) | 1 | 0 | (0.09) | 0 | 1 | (0.1) | |
| N+ | + | 16 | 3 | NS 0.7 | 17 | 2 | 0.01 | 4 | 15 | NS 0.6 |
| - | 1 | 0 | (0.1) | 0 | 1 | (0.5) | 0 | 1 | (0.1) | |
| M+ | + | 19 | 4 | NS 0.7 | 19 | 2 | 0.01 | 10 | 12 | NS 0.7 |
| - | 1 | 0 | (0.1) | 1 | 2 | (0.5) | 1 | 2 | (0.07) | |
Positive tumoral expression of VEGFR-1 is positively correlated with positive tumoral VEGF expression in the tumor center and positive tumoral PlGF expression in the tumor center and tumor budding regions. r = Spearman’s rank correlation coefficient. p < 0.05 was taken as statistically significant. NS, not significant.