Table 5.
Numerical and percentage distribution of VEGFR-1/pVEGFR-1 co-expression tumor cells
| N0/M0 n (%) | N+ n (%) | N0/M0 vs. N + p | M+ n (%) | N0/M0 vs. M + p | |
|---|---|---|---|---|---|
| Co-expression in the tumor center | |||||
| VEGFR-1+/pVEGFR-1Tyr1048+ | 36/32 (89) | 19/13 (68) | NS 0.08 | 21/13 (62) | 0.02 |
| VEGFR-1+/pVEGFR-1Tyr1213+ | 36/28 (78) | 19/12 (63) | NS 0.3 | 21/10 (48) | 0.02 |
| VEGFR-1+/pVEGFR-1Tyr1333+ | 36/22 (61) | 19/9 (47) | NS 0.4 | 21/10 (48) | NS 0.4 |
| Co-expression in tumor budding regions | |||||
| VEGFR-1+/pVEGFR-1Tyr1048 + | 26/25 (96) | 19/13 (68) | 0.02 | 22/14 (64) | 0.005 |
| VEGFR-1+/pVEGFR-1Tyr1213 + | 26/21 (81) | 19/9 (47) | 0.02 | 22/11 (50) | 0.01 |
| VEGFR-1+/pVEGFR-1Tyr1333 + | 26/13 (50) | 19/9 (47) | NS 1.0 | 22/9 (41) | NS 0.6 |
n: total number of VEGFR-1 positive cases/total number of pVEGFR-1 positive cases with concomitant VEGFR-1 positivity. p < 0.05 statistically significant, NS not significant.