Table 2.
Categorization of single-nucleotide variants in 77 breast cancer tumors using dGene: 37 dGene entries present in at least 2 out of 77 samples, organized by class and patients affected
| NCBI symbol | Full name | dGene class | Patients affected |
|---|---|---|---|
| CASR | Calcium-sensing receptor | G protein-coupled receptor | 3 |
| GPR112 | G protein-coupled receptor 112 | G protein-coupled receptor | 3 |
| AGTR2 | Angiotensin II receptor, type 2 | G protein-coupled receptor | 2 |
| MC5R | Melanocortin 5 receptor | G protein-coupled receptor | 2 |
| OR2L2 | Olfactory receptor, family 2, subfamily L, member 2 | G protein-coupled receptor | 2 |
| OR51B5 | Olfactory receptor, family 51, subfamily B, member 5 | G protein-coupled receptor | 2 |
| PIK3CA | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | PI3K | 37 |
| BIRC6 | Baculoviral IAP repeat containing 6 | Proteinase inhibitor | 4 |
| CPAMD8 | C3 and PZP-like, α-2-macroglobulin domain containing 8 | Proteinase inhibitor | 3 |
| COL28A1 | Collagen, type XXVIII, alpha 1 | Proteinase inhibitor | 2 |
| COL6A3 | Collagen, type VI, alpha 3 | Proteinase inhibitor | 2 |
| AGBL1 | ATP/GTP binding protein-like 1 | Protease | 2 |
| CPVL | Carboxypeptidase, vitellogenic-like | Protease | 2 |
| PCSK5 | Proprotein convertase subtilisin/kexin type 5 | Protease | 2 |
| RELN | Reelin | Protease | 2 |
| SENP7 | SUMO1/sentrin specific peptidase 7 | Protease | 2 |
| USP9X | Ubiquitin specific peptidase 9, X-linked | Protease | 2 |
| PTPRF | Protein tyrosine phosphatase, receptor type, F | Phosphatase | 2 |
| PTPRU | Protein tyrosine phosphatase, receptor type, U | Phosphatase | 2 |
| SSH3 | Slingshot homolog 3 (Drosophila) | Phosohatase | 2 |
| MAP3K1 | Mitogen-activated protein kinase kinase kinase 1 | Serine theonine kinase | 9 |
| TTN | Titin | Serine theonine kinase | 6 |
| ATR | Ataxia telangiectasia and Rad3 related | Serine theonine kinase | 5 |
| OBSCN | Obscurin | Serine theonine kinase | 3 |
| SMG1 | Smg-1 homolog | Serine theonine kinase | 3 |
| ALPK2 | Alpha-kinase 2 | Serine theonine kinase | 2 |
| BRAF | V-raf murine sarcoma viral oncogene homolog B1 | Serine theonine kinase | 2 |
| DCLK3 | Doublecortin-like kinase 3 | Serine theonine kinase | 2 |
| LRRK2 | Leucine-rich repeat kinase 2 | Serine theonine kinase | 2 |
| MAP2K4 | Mitogen-activated protein kinase kinase 4 | Serine theonine kinase | 2 |
| TAF1L | TATA box binding protein (TBP)-associated factor | Serine theonine kinase | 2 |
| TBK1 | TANK-binding kinase 1 | Serine theonine kinase | 2 |
| ULK4 | Unc-51-like kinase 4 | Serine theonine kinase | 2 |
| INSRR | Insulin receptor-related receptor | Tyrosine kinase | 3 |
| KIT | C-kit | Tyrosine kinase | 2 |
| PDGFRA | Platelet-derived growth factor receptor | Tyrosine kinase | 2 |
| TEX14 | Testis expressed 14 | Tyrosine kinase | 2 |
NCBI, National Center for Biotechnology Information.