Table 3.
Disease-specific survival (DSS) for GIST patients <50 years (sub-cohort I, “young” ) versus ≥50 years (sub-cohort II, “old” ) related to GIST relevant clinicopathological parameters
| Parameter | Disease-specific survival (DSS) rates | p-value1 | ||||||
|---|---|---|---|---|---|---|---|---|
| Sub-cohort I (“young”) | Sub-cohort II (“old”) | |||||||
| n = 87 | n = 125 | |||||||
| 1 yr | 3 yr | 5 yr | 1 yr | 3 yr | 5 yr | |||
| Sex | male | 96.9% | 92,3% | 92,3% | 97,8% | 84,8% | 78,5% | 0.326 |
| female | 100% | 100% | 100% | 94,7% | 88,6% | 83,2% | 0.008 | |
| p-value 2 | 0.033 | 0.596 | ||||||
| Localization | Gaster | 97,2% | 97,2% | 97,2% | 97,0% | 88,0% | 83,4% | 0.036 |
| Small intestine | 100% | 93,8% | 93,8% | 96,4% | 88,5% | 78,6% | 0.267 | |
| p-value 2 | 0.225 | 0.813 | ||||||
| Histotype | Spindle | 100% | 97,4% | 97,4% | 96,4% | 90,8% | 83,5% | 0.028 |
| epitheliod/mixed | 100% | 100% | 100% | 91,7% | 66,7% | 66,7% | 0.061 | |
| p-value 2 | 0.695 | 0.097 | ||||||
| Size | <1 cm | - | - | - | 100,0% | 100,0% | 85,7% | - |
| ≥1 cm | 100% | 97,9% | 97,9% | 96,6% | 87,5% | 82,6% | 0.012 | |
| p-value 2 | - | 0.499 | ||||||
| Size | <5 cm | 96,8% | 92,2% | 92,2% | 100,0% | 94,5% | 90,9% | 0.630 |
| ≥5 cm | 100% | 100% | 100% | 94,1% | 83,8% | 76,3% | 0.008 | |
| p-value 2 | 0.462 | 0.012 | ||||||
| Size | <10 cm | 97,9% | 95,0% | 95,0% | 98,6% | 95,3% | 93,1% | 0.839 |
| ≥10 cm | 100% | 100% | 100% | 92,0% | 71,1% | 56,0% | 0.010 | |
| p-value 2 | 0.759 | <0.001 | ||||||
| Mitotic rate | <5 / 50 HPF | 100% | 100% | 100% | 98,4% | 96,2% | 90,4% | 0.131 |
| ≥5 / 50 HPF | 100% | 100% | 100% | 91,6% | 73,7% | 66,7% | 0.026 | |
| p-value 2 | 0.038 | 0.001 | ||||||
| Mitotic rate | <10 / 50 HPF | 100% | 100% | 100% | 97,4% | 92,4% | 88,2% | 0.043 |
| ≥10 / 50 HPF | 100% | 100% | 100% | 89,7% | 68,6% | 56,1% | 0.025 | |
| p-value 2 | <0.001 | <0.001 | ||||||
| Risk (NIH) | high | 100% | 100% | 100% | 87,9% | 68,4% | 60,8% | 0.004 |
| non-high | 100% | 100% | 100% | 100,0% | 98,0% | 92,9% | 0.227 | |
| p-value | 0.027 | <0.001 | ||||||
| Risk (AFIP) | high | 100% | 100% | 100% | 89,4% | 70,5% | 61,7% | 0.018 |
| non-high | 100% | 100% | 100% | 98,5% | 94,4% | 89,4% | 0.084 | |
| p-value | 0.013 | <0.001 | ||||||
1Unadjustedp-values comparing data from study-cohort I vs. II considering DSS after 5 year follow-up.
2Unadjusted p-values comparing data within study-cohort I and II considering DSS rates after 5 year follow-up.