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. 2015 Apr 3;10:14. doi: 10.1186/s13062-015-0045-x

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© Stubbington et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Alternative splicing of the gene encoding CD45 ( Ptprc ). (A) The first exons of the two Ptprc isoforms (Ptprc-201, Ptprc-202) annotated in the ENSEMBL GRCm38v70 mouse genome. Exons 4–6 (highlighted by grey box) are skipped in Ptprc-202 leading to a shorter transcript that is preferentially expressed following T cell activation. (B) Relative expression of Ptprc splice isoforms in the CD4⁺ subtypes was estimated using the mixture-of-isoforms (MISO) model to calculate percent spliced in (PSI) values for each isoform in each subtype.