Table 4. Characteristics of Pseudomonas aeruginosa clinical isolates producing metallo-β-lactamase.
| Isolate | ST | MBL genotype | MIC (mg/L) | Co-resistant to: | |
|---|---|---|---|---|---|
| IPM | MEM | ||||
| GS8 | 235 | blaIMP-6 | >32 | >32 | AMK, AMC, ATM, FEP, CAZ, CIP, GEN, TET, TIM, TOB, TMP/SMT |
| CSU13 | 235 | blaIMP-6 | >32 | >32 | AMC, ATM, FEP, CAZ, CIP, TZP, TET, TIM, TMP/SMT |
| UUS6 | 235 | blaIMP-6 | >32 | >32 | AMK, AMC, ATM, FEP, CAZ, CIP, GEN, TZP, TET, TIM, TOB, TMP/SMT |
| UUS7 | 235 | blaIMP-6 | >32 | >32 | AMK, AMC, ATM, FEP, CAZ, CIP, GEN, TZP, TET, TIM, TOB, TMP/SMT |
| UUS15 | 235 | blaIMP-6 | >32 | >32 | AMK, AMC, ATM, FEP, CAZ, CIP, GEN, TZP, TET, TIM, TOB, TMP/SMT |
| CMSEO8 | 235 | blaIMP-6 | >32 | >32 | AMK, AMC, ATM, FEP, CAZ, CIP, GEN, TET, TIM, TOB, TMP/SMT |
| CNU7 | 235 | blaIMP-6 | >32 | >32 | AMK, AMC, ATM, FEP, CAZ, CIP, GEN, TET, TIM, TOB, TMP/SMT |
| SCHGM7 | 235 | blaIMP-6 | >32 | >32 | AMK, AMC, ATM, FEP, CAZ, CIP, GEN, TZP, TET, TIM, TOB, TMP/SMT |
| CMEUI9 | 235 | blaIMP-6 | >32 | >32 | AMC, ATM, FEP, CIP, TET, TMP/SMT |
| CMDAE14 | 235 | blaIMP-6 | >32 | >32 | AMK, AMC, ATM, FEP, CAZ, CIP, GEN, TZP, TET, TIM, TOB, TMP/SMT |
| BUPAIK7 | 235 | blaIMP-6 | >32 | >32 | AMK, AMC, ATM, FEP, CAZ, CIP, GEN, TZP, TET, TIM, TOB, TMP/SMT |
| BUPAIK15 | 235 | blaIMP-6 | >32 | >32 | AMK, AMC, ATM, FEP, CAZ, CIP, GEN, TET, TIM, TOB, TMP/SMT |
| JNU2 | 235 | blaIMP-6 | >32 | >32 | AMK, AMC, FEP, CAZ, CIP, GEN, TZP, TET, TIM, TOB, TMP/SMT |
| JNU3 | 235 | blaIMP-6 | >32 | >32 | AMK, AMC, FEP, CAZ, CIP, GEN, TZP, TET, TIM, TOB, TMP/SMT |
| JNU13 | 235 | blaIMP-6 | >32 | >32 | AMK, AMC, FEP, CAZ, CIP, GEN, TET, TIM, TOB, TMP/SMT |
| JBNU1 | 235 | blaIMP-6 | >32 | >32 | AMK, AMC, ATM, FEP, CAZ, CIP, GEN, TZP, TET, TIM, TOB, TMP/SMT |
| BC3 | 463 | blaIMP-6 | >32 | >32 | AMK, AMC, ATM, FEP, CAZ, CIP, GEN, TET, TIM, TOB, TMP/SMT |
| JBNU5 | 235 | blaVIM-2 | >32 | >32 | AMK, AMC, CAZ, CIP, GEN, TZP, TET, TIM, TOB, TMP/SMT |
| JBNU9 | 235 | blaVIM-2 | >32 | >32 | AMK, AMC, ATM, FEP, CAZ, CIP, GEN, TZP, TET, TIM, TOB, TMP/SMT |
| CMIN8 | 235 | blaVIM-2 | >32 | >32 | AMC, FEP, CAZ, TET, TIM, TMP/SMT |
| UUS4 | 309 | blaVIM-2 | >32 | 2 | AMK, AMC, ATM, FEP, CAZ, CIP, GEN, TET, TIM, TOB, TMP/SMT |
ST, sequence type; MBL, metallo-β-lactamase; MIC, minimum inhibitory concentration; IPM, imipenem; MEM, meropenem; AMK, amikacin; AMC, amoxicillin-clavulanic acid; ATM, aztreonam; FEP, cefepime; CAZ, ceftazidime; CIP, ciprofloxacin; GEN, gentamicin; TET, tetracycline; TIM, ticarcillin-clavulanic acid; TOB, tobramycin; TMP/SMT, trimethoprim-sulfamethoxazole; TZP, piperacillin-tazobactam.