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. Author manuscript; available in PMC: 2015 Apr 3.
Published in final edited form as: Circ Cardiovasc Imaging. 2015 Feb;8(2):e001952. doi: 10.1161/CIRCIMAGING.114.001952

Figure 4.

Figure 4

A, Heart explanted from doxorubicin-treated (Doxo) mice and mice treated with vehicle (control) was fixed and 10 μm sections of myocardium were placed on an imaging plate and exposed overnight at −80°C for autoradiography. Doxorubicin treatment for 3, 6, and 12 weeks was associated with increase in 18F-CP18 uptake of myocardial tissue sections compared with minimal 18F-CP18 uptake seen in control. Regions in red represent foci with high uptake, yellow and green represent intermediate uptake, and blue represents background. Each slide contains myocardial sections from the base, mid, and distal segments of the heart from 1 individual animal. B, 18F-CP18 uptake was quantified by measuring count densities using an FLA-7000 scanner. An image analysis software was used to quantify signal intensity of 18F-CP18 retained in the myocardium and expressed as PSL/mm2. Data points represent median and interquartile range of 18F-CP18 uptake in 3 to 4 myocardial tissue sections from 3 mice each at weeks 1, 3, 6, and 12 of treatment.