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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: ChemMedChem. 2014 Oct 22;10(2):380–395. doi: 10.1002/cmdc.201402374

Scheme 2.

Scheme 2

Synthesis of O-(triazol-4-yl)alkyl carbamates 17-30, 32-33. Reagents and conditions: a) prop-2-yn-1-yl N-cyclohexylcarbamate, sodium L-ascorbate, copper (II) sulfate pentahydrate, H2O-tert-BuOH 1:1, rt, 3h; a’) but-3-yn-1-ol, sodium L-ascorbate, copper (II) sulfate pentahydrate, H2O-tert-BuOH 1:1, rt, 3h; b’) cyclohexyl isocyanate, DMAP, dry MeCN, 80 °C, 5h.