Table 1.

FAAH inhibitory activity and rat plasma stability of 1a, 4, and O-[1-substituted-(1,2,3-triazol-4-yl)]alkyl carbamates

Compounds	Structure	IC50 [nM]a	Plasma half-life (min.)	% remaining after 7 hb
1a		5.7 ± 1.2	62 ± 19	0
4		65% @ 100 μM	-	-
17		380.6 ± 62.9	-	90 ± 9
18		26.2 ± 3.8	-	92 ± 8
19		833 ± 129	-	-
32		1278 ± 84	-	-
33		2535 ± 106	-	-
43		70% @ 100 μM	-	-
46		51500 ± 1125	-	-

^aIC₅₀ values are reported as the mean ± SEM (n= 3);

^bPercent of parent compound remaining after 7 h incubation.