Table 2.

FAAH inhibitory activity of O-(triazol-4-yl)methyl carbamates variously substituted at region C.

Cpds	R	IC50 [nM]a	Cpds	R	IC50 [nM]a
20		73% @ 100 μM	25a		21.5 ± 1.2
21		2003 ± 636	25b		24.5 ± 6.2
22a		19.5 ± 4.3	25c		500 ± 44
22b		21.5 ± 7.9	26a		1.4 ± 0.2
22c		2282 ± 585	26b		11.8 ± 3.7
23a		9.9 ± 1.9	26c		627 ± 173
23b		12.1 ± 0.8	27		10.5 ± 2.9
23c		95.5 ± 22.2	28		11.9 ± 1.0
24a		6.2 ± 1.3	29		10.4 ± 2.6
24b		13.2 ± 2.8	30		44.6 ± 10.3
24c		215 ± 31

^aIC₅₀ values are reported as the mean ± SEM (n= 3).