Table 3.
FAAH inhibitory activity of N-(triazol-4-yl)methyl O-(triazol-4-yl)methyl carbamates 34a-40.
| Compounds | Structure | −IC50 [nM]a |
|---|---|---|
| 34a |
|
154 ± 14 |
| 34b |
|
3.9 ± 0.7 |
| 37 |
|
3.2 ± 1.2 |
| 38 |
|
7.6 ± 0.6 |
| 39 |
|
9.8 ± 0.1 |
| 40 |
|
5.8 ± 0.6 |
IC50 values are reported as the mean ± SEM (n= 3).