Table 5.

Characterization of selected compounds

Cp d	Structure	r- FAA H IC50 [nM]a	h -FAA H IC50 [nM]a	Plasm a Stab. (% at 7 h)b	MLM Stab. half- life (min.) c	Kineti c sol. (μM)d
1a		5.7 ± 1.2	3.1 ± 1.3	0	<5	6
27		10.5 ± 2.9	3.6 ± 0.9	91 ± 3	5	18
34b		3.9 ± 0.7	4.2 ± 1.0	88 ± 11	6	174
40		5.8 ± 0.6	9.4 ± 2.0	89 ± 9	8	152

^aIC₅₀ values for FAAH inhibition are reported as the mean ± SEM (n= 3);

^bData are the mean ± SEM of three determinations;

^cData are the mean of three determinations;

^dPhosphate buffered saline, pH 7.4, single determination.