. Author manuscript; available in PMC: 2015 Apr 3.

Published in final edited form as: Future Med Chem. 2014 May;6(8):945–966. doi: 10.4155/fmc.14.44

Table 6.

Sirtuin inhibitors: Indole derivatives

Entry #	Structure	IC₅₀	Biology Activity
1	EX527	SIRT1: 60–100 nM[127]	Induced apoptosis in leukemia cell when combined with HDAC inhibitors[135]; protected against OPMD [119]
2	AC-93253	SIRT1: 45.3 μM SIRT2: 6 μM SIRT3: 24.6 μM[48]	Cytotoxic effects in prostate DU145, pancreas MiaPaCa, lung A549 and NCI-H460 cancer cell lines[48]
3	Inauhzin (INZ)	SIRT1: 0.7–2 μM[130]	Inhibited cell proliferation, induced senescence and apoptosis of human cancer cell without genotoxicity, and repressed the growth of xenograft tumors derived from human lung cancer H460 and colon cancer HCT116 cells harbouring p53[130].
4	Ro31-8220	SIRT1: 3.5 μM SIRT2: 0.8 μM[132]
5	GW5074	SIRT1: 41.6 μM [133] SIRT2: 15.6 μM [133] SIRT3: 25.1 μM [133] SIRT5: 19.5 μM [134]