Table 6.
Entry # | Structure | IC50 | Biology Activity |
---|---|---|---|
1 | EX527 |
SIRT1: 60–100 nM[127] | Induced apoptosis in leukemia cell when combined with HDAC inhibitors[135]; protected against OPMD [119] |
2 | AC-93253 |
SIRT1: 45.3 μM SIRT2: 6 μM SIRT3: 24.6 μM[48] |
Cytotoxic effects in prostate DU145, pancreas MiaPaCa, lung A549 and NCI-H460 cancer cell lines[48] |
3 | Inauhzin (INZ) |
SIRT1: 0.7–2 μM[130] | Inhibited cell proliferation, induced senescence and apoptosis of human cancer cell without genotoxicity, and repressed the growth of xenograft tumors derived from human lung cancer H460 and colon cancer HCT116 cells harbouring p53[130]. |
4 | Ro31-8220 |
SIRT1: 3.5 μM SIRT2: 0.8 μM[132] |
|
5 | GW5074 |
SIRT1: 41.6 μM [133] SIRT2: 15.6 μM [133] SIRT3: 25.1 μM [133] SIRT5: 19.5 μM [134] |