Table 9.
Entry # | Structure | IC50 | Biology Activity |
---|---|---|---|
1 | AGK2 |
SIRT1: >50 μM SIRT2: 3.5 μM SIRT3: >50 μM[140] |
Protective against Parkinson’s disease[140,143]; potent against glioblastoma multiforme CSCs[118] |
2 | Aristoforin |
SIRT1: 7 μM SIRT2: 21 μM[141] |
Anti-proliferative activity on HUVEC cells[141] |
3 | SIRT1: 1 μM[142] | Anti-proliferative in MAD-MB-231 and MCF7 cancer cell lines[142]; | |
4 | Tanikolide Dimer |
SIRT1: 36.4 μM SIRT2: 3.3 μM[144] |
|
5 | SIRT2: 1.5 μM[145] | ||
6 | SIRT1: 15 nM SIRT2: 10 nM SIRT3: 33 nM [146] |
||
7 | SIRT1: 4.3 nM SIRT2: 1.1 nM SIRT3: 7.2 nM [146] |