Table 9.

Other sirtuin inhibitors

Entry #	Structure	IC50	Biology Activity
1	AGK2	SIRT1: >50 μM SIRT2: 3.5 μM SIRT3: >50 μM[140]	Protective against Parkinson’s disease[140,143]; potent against glioblastoma multiforme CSCs[118]
2	Aristoforin	SIRT1: 7 μM SIRT2: 21 μM[141]	Anti-proliferative activity on HUVEC cells[141]
3		SIRT1: 1 μM[142]	Anti-proliferative in MAD-MB-231 and MCF7 cancer cell lines[142];
4	Tanikolide Dimer	SIRT1: 36.4 μM SIRT2: 3.3 μM[144]
5		SIRT2: 1.5 μM[145]
6		SIRT1: 15 nM SIRT2: 10 nM SIRT3: 33 nM [146]
7		SIRT1: 4.3 nM SIRT2: 1.1 nM SIRT3: 7.2 nM [146]