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. Author manuscript; available in PMC: 2016 Mar 15.
Published in final edited form as: Biochem J. 2015 Mar 15;466(3):625–637. doi: 10.1042/BJ20141202

Figure 8. A model describing the role of ESCRT-II in activating VPS-20 during intralumenal vesicle formation at multivesicular endosomes.

Figure 8

The model highlights that VPS-20 exhibits an open conformation independently of ESCRT-II. However, upon binding ESCRT-II, VPS-20 is capable of sensing regions of elevated membrane curvature (e.g., at the forming neck of inward budding vesicles on endosomes), and restricting ESCRT-III distribution to these bent lipid bilayers.