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. Author manuscript; available in PMC: 2015 Apr 3.
Published in final edited form as: Dev Biol. 2014 Jan 21;387(2):167–178. doi: 10.1016/j.ydbio.2014.01.010

Fig. 8.

Fig. 8

Dkk2/Frzb regulates feather axis formation. (A–D) Micro-bead mediated antibody delivery into the feather follicle induces two feathers from a single follicle (marked by*). Two feather vanes were formed in 20% (3/15) of the cases. Control antiserum delivery caused no abnormality in the feather (n = 5). (E–H) Lentiviral-mediated overexpression of Frzb or RNAi knockdown of Dkk2 produced two feather axes, and to a less extent, two feather vanes in 20% of the cases (3/15). No abnormality was produced by an empty viral vector pLVX transduction in the control feather follicles (n = 10), or LV-Dkk3 transduced feather follicles (n = 10). Bar = 1 cm (shown in H).