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. Author manuscript; available in PMC: 2015 Apr 3.
Published in final edited form as: Eur J Neurosci. 2011 Nov 18;34(11):1737–1746. doi: 10.1111/j.1460-9568.2011.07891.x

Fig. 2.

Fig. 2

Effect of elevated RhoB activity on neuronal caspase 3 activity. (A–D) caRhoB and STS induce caspase 3 activation. Upper images in each pair show GFP-labelled neuronal soma (A–D), and lower images in each pair show the corresponding active caspase 3-immunoreactivity (red) (A′–D′). Scale bar = 10 µm. (E) Effect of RhoB expression and STS on active caspase 3-immunoreactivity in corticohippocampal neurons. Results are shown as percentage of signal in control (vehicle-treated, GFP-transfected) neurons, and are mean ± SEM, n = 8–16 per group. Effect of vector: F1,53 = 10.67, P < 0.01; effect of STS: F1,53 = 15.90, P < 0.001 (anova). *P < 0.05 vs. control (Veh-GFP) (Tukey’s post-hoc test); #P < 0.05 vs. Veh-RhoB. (F) Effect of elevated RhoB activity on caspase activity in response to STS exposure in NG108-15 cells. Results are shown as mean ± SEM, n = 6 per group. Effect of vector: F1,17 = 4.89, P < 0.05; effect of STS: F1,17 = 610.17, P < 0.001 (anova – transformed data). #P < 0.05 vs. control (Veh-GFP) (Mann–Whitney test). For interpretation of color references in figure legend, please refer to the Web version of this article.

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