Fig. 5.
Altered initiator caspase responses in corticohippocampal neurons lacking RhoB. (A) Caspase 8 activity and (B) caspase 9 activity in primary cortico-hippocampal cultures from WT and RhoB KO mice, treated for 4 h with vehicle, or either 200 or 500 nm STS. Results are shown as mean ± SEM, n = 8 per group. Two-way anova: caspase 8 activity, effect of STS concentration – F2,47 = 23.5, P < 0.001, effect of genotype – F2,47 = 0.51, P = 0.48; caspase 9 activity, effect of STS concentration – F2,47 = 162.9, P < 0.001, effect of genotype – F1,47 = 14.0, P < 0.001. ***P < 0.001 vs. corresponding WT value, post-hoc Tukey’s test.