Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Mar 30;208(7):931–947. doi: 10.1083/jcb.201404066

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 West et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 8. — Rab8 mutants reveal a role for the JNKKK TAK1 in synaptic overgrowth at the NMJ. (A and B) Loss of TAK1 function generated by Inhibition of TAK1 through panneuronal (n-Syb–Gal4) expression of a dominant-negative form of TAK1, knockdown by TAK1-RNAi, or use of a TAK1 loss-of-function allele completely alleviated synaptic overgrowth in a Rab8 mutant background. Correspondingly panneuronal expression of UAS-TAK1 promotes synaptic overgrowth, characterized by a significant increase in synaptic bouton number. Reduction of HRS function, using a heterozygous HRS loss-of-function allele HRS^D28/+, in combination with Rab8¹/+ elicited a significant increase in synaptic bouton number. HRS^D28/+ or Rab8¹/+ alone did not affect bouton number. Bar, 10 µm. ANOVA: F (d.f. 11) = 24.2733; P < 0.001 with post-hoc Dunnett’s comparison to wild-type control: ***, P < 0.001. Student’s t test comparison between genotypes: ###, P < 0.001; #, P < 0.05. Numbers above bars = n. Error bars show SEM.