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. 2015 Mar 30;208(7):881–896. doi: 10.1083/jcb.201412085

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© 2015 Moudgil et al.

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Figure 8. — A proposed model of hSpindly KT localization. (A) A schematic representation of hSpindly domains and posttranslational modifications. SB, Spindly box. (B) hSpindly farnesylation induces a conformational change such that it can interact with the RZZ complex subunits Rod and Zwilch, which recruits hSpindly to KTs during mitosis. hSpindly further recruits the dynein–dynactin complex to KTs. Once all the chromosomes are aligned on the metaphase plate, hSpindly and the RZZ complex are transported from the KTs to spindle poles.