Table 3.
Chronic Obstructive Pulmonary Disease Outcome Measures among Subjects with Chronic Obstructive Pulmonary Disease with Intermediate/High Risk and Low Risk of Occupational Exposure
| All Smokers with COPD (n = 721) | JEM Low Risk of Exposure (n = 438) | JEM Intermediate/High Risk of Exposure (n = 283) | P Value | |
|---|---|---|---|---|
| COPD severity | ||||
| 6MWD, m; mean (SD) | 392.2 (112.3) | 396.8 (110.9) | 385.0 (114.4) | 0.18 |
| Post-bronchodilator FEV1% predicted, mean (SD) | 61.2 (23.4) | 62.5 (23.6) | 59.2 (22.9) | 0.08 |
| mMRC, mean (SD) | 1.2 (1.0) | 1.1 (0.9) | 1.3 (1.0) | 0.01 |
| CAT, mean (SD) | 14.6 (7.6) | 13.8 (7.3) | 15.8 (7.8) | 0.001 |
| HRQOL | ||||
| SGRQ, mean (SD) | 35.5 (18.9) | 33.2 (18.2) | 38.7 (19.6) | 0.0002 |
| SF-12 Physical, mean (SD) | 27.1 (10.5) | 28.4 (10.3) | 25.2 (10.5) | 0.0001 |
| COPD exacerbation over past 12 mo, n (% reporting) | ||||
| Requiring HCU | 180 (25.0) | 95 (21.7) | 85 (30.1) | 0.01 |
| Requiring meds | 171 (23.8) | 98 (22.4) | 73 (25.9) | 0.28 |
Definition of abbreviations: CAT = COPD Assessment Test; COPD = chronic obstructive pulmonary disease; HCU = health care utilization; HRQOL = health-related quality of life; JEM = job exposure matrix; mMRC = modified Medical Research Council Dyspnea Scale; SF-12 Physical = Short-Form Health Survey physical component scale; SGRQ = St. George’s Respiratory Questionnaire; 6MWD = 6-minute-walk distance.