Table 2.
Replicated SNPs among the Top 42 SHARP P Values for FEV1 Change
| SNP | Chr | Base Pair | Allele | CAMP/CARE β Estimate | CAMP/CARE P Value | ACRN β Estimate | ACRN P Value | SHARP Combined P Value | SHARP Combined β Estimate | Replication β Estimate | Replication P Value (One-sided) | Overall P Value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs350729 | 2 | 52837277 | 4 | −2.22 | 3.3 × 10−4 | −3.65 | 4.16 × 10−4 | 3.04 × 10−7 | −2.26 | −5.63 | 7.45 × 10−5 | 2.21 × 10−10* |
| rs1840321 | 2 | 52814911 | 2 | −1.91 | 1.41 × 10−3 | −2.28 | 1.96 × 10−2 | 4.71 × 10−5 | −1.59 | −5.17 | 8.5 × 10−5 | 5.75 × 10−8* |
| rs1384918 | 2 | 52827838 | 3 | −1.86 | 1.83 × 10−3 | −2.29 | 1.94 × 10−2 | 6.24 × 10−5 | −1.57 | −5.08 | 1.07 × 10−4 | 9.3 × 10−8* |
| rs1319797 | 2 | 52822533 | 3 | −2.00 | 9.62 × 10−4 | −2.40 | 1.44 × 10−2 | 2.28 × 10−5 | −1.66 | −5.00 | 1.52 × 10−4 | 3.95 × 10−8* |
| rs785291 | 2 | 52871781 | 2 | 1.99 | 1.23 × 10−4 | 2.04 | 3.39 × 10−2 | 5.04 × 10−5 | 1.64 | 3.67 | 4.21 × 10−3 | 1.34 × 10−6 |
Definition of abbreviations: ACRN = Asthma Clinical Research Network; CAMP = Childhood Asthma Management Program; CARE = Childhood Asthma Research and Education; Chr = chromosome; SHARP = SNP Health Association Resource (SHARe) Asthma Resource Project; SNP = single-nucleotide polymorphism.
*
Significant at α = 0.05 after correction for multiple comparisons.