Table 4.
The association between polymorphisms in Pvmdr1 gene at the 4 highly polymorphic loci (S513R, Y976F, F1076L, T529) including the other 5 loci and in vitro susceptibilities of 15 selected P. vivax isolates to chloroquine classified based on the in vitro IC50 cut-off of 100 nM
| Chloroquine resistant | Chloroquine sensitive | ||
|---|---|---|---|
| S513R | S | 7 | 5 |
| R | 2 | 1 | |
| S515R | R | 6 | 9 |
| T529 | T (aca) | 0 | 1 |
| T (acg) | 9 | 5 | |
| G698S | S | 9 | 6 |
| M908L | L | 9 | 6 |
| T958M | M | 9 | 6 |
| Y976F | F | 1 | 1 |
| Y | 8 | 5 | |
| L1022 | L (cta) | 9 | 6 |
| F1076L | F | 3 | 3 |
| L | 6 | 3 |
Data are presented as number of isolates (n).