Table 1.
Expressed subunits | Expression system | GABA [μM] | Iabs [μA] | Modulator | GABA + modulator [μM] | Iabs [μA] | Irel [% of 1 μM GABA] | n | Originally identified in Sideritis extract |
---|---|---|---|---|---|---|---|---|---|
Rat α1β2 | Xenopus oocytes | ||||||||
1 | 0.41 ± 0.07 | α-Phellandrene | 1000 | 0.46 ± 0.08 | 112 ± 19 | 3 | * | ||
1 | 0.24 ± 0.06 | β-Pinene | 1000 | 0.35 ± 0.08 | 134 ± 31 | 7 | * | ||
1 | 0.26 ± 0.05 | Linalool | 1000 | 1.23 ± 0.25 | 473 ± 96 | 4 | * | ||
1 | 1.99 ± 0.64 | 1-Octen-3-ol | 1000 | 6.40 ± 1.74 | 321 ± 87 | 4 | * | ||
1 | 0.58 ± 0.13 | Carveol | 600 | 1.71 ± 0.26 | 294 ± 45 | 10 | |||
1 | 0.31 ± 0.10 | Pinocarveol | 600 | 1.11 ± 0.32 | 358 ± 103 | 7 | |||
1 | 0.30 ± 0.04 | Isopulegol | 600 | 1.25 ± 0.43 | 416 ± 143 | 8 | |||
1 | 0.18 ± 0.09 | Carvacrol | 300 | 0.44 ± 0.22 | 414 ± 142 | 5 | * | ||
1 | 0.55 ± 0.25 | Myrtenol | 300 | 2.55 ± 1.00 | 463 ± 181 | 7 | |||
1 | 0.38 ± 0.16 | Verbenol | 300 | 1.00 ± 0.38 | 263 ± 99 | 7 | |||
1 | 0.25 ± 0.08 | α-Pinene | 1000 | 0.35 ± 0.08 | 140 ± 32 | 7 | * | ||
1 | 0.23 ± 0.05 | Myrcene | 1000 | 0.34 ± 0.06 | 147 ± 26 | 7 | * | ||
1 | 0.22 ± 0.04 | Caryophyllene oxide | 1000 | 0.24 ± 0.04 | 109 ± 18 | 7 | * | ||
1 | 0.052 ± 0.029 | Sabinene | 1000 | 0.057 ± 0.034 | 109 ± 65 | 4 | * | ||
1 | 0.04 ± 0.02 | β-Caryophyllene | 1000 | 0.085 ± 0.04 | 212 ± 99 | 4 | * | ||
1 | 0.09 ± 0.04 | α-Terpeniol | 1000 | 0.16 ± 0.06 | 177 ± 66 | 3 | * | ||
1 | 0.51 ± 0.09 | Cedrol | 600 | 1.09 ± 0.18 | 213 ± 35 | 11 | |||
1 | 0.53 ± 0.09 | Nerolidol | 600 | 0.73 ± 0.11 | 137 ± 21 | 11 | |||
1 | 0.46 ± 0.28 | 2-Methyl-3-buten-2-ol | 600 | 1.19 ± 0.28 | 258 ± 61 | 8 | |||
1 | 0.59 ± 0.13 | β-Citronellol | 600 | 0.99 ± 0.18 | 167 ± 30 | 10 | |||
1 | 0.26 ± 0.05 | α-Santonin | 600 | 0.57 ± 0.12 | 219 ± 46 | 3 | |||
1 | 0.31 ± 0.09 | Theaspiran | 600 | 0.68 ± 0.15 | 219 ± 48 | 7 | |||
1 | 0.84 ± 0.27 | α-Thujone | 600 | 0.52 ± 0.20 | 62 ± 24 | 3 | |||
1 | 0.33 ± 0.06 | Terpinolene | 600 | 0.69 ± 0.16 | 209 ± 48 | 6 | |||
1 | 0.37 ± 0.07 | Myrtenal | 600 | 0.89 ± 0.18 | 240 ± 48.5 | 8 | |||
1 | 0.31 ± 0.02 | Nootkatone | 600 | 0.46 ± 0.06 | 148 ± 19 | 7 | |||
Human α1β2γ2 | Xenopus oocytes | ||||||||
1 | 0.79 ± 0.25 | Linalool | 300 | 1.69 ± 0.84 | 213 ± 105 | 10 | |||
1 | 0.22 ± 0.05 | 1-Octen-3-ol | 300 | 0.65 ± 0.11 | 295 ± 50 | 6 | |||
1 | 0.13 ± 0.08 | Carveol | 300 | 0.59 ± 0.23 | 453 ± 176 | 8 | |||
1 | 0.35 ± 0.08 | Pinocarveol | 300 | 1.67 ± 0.24 | 477 ± 68 | 8 | |||
1 | 0.49 ± 0.13 | Isopulegol | 300 | 1.67 ± 0.035 | 340 ± 70 | 7 | |||
1 | 1.72 ± 0.64 | Carvacrol | 300 | 3.86 ± 1.46 | 224 ± 85 | 6 | |||
1 | 0.35 ± 0.12 | Myrtenol | 300 | 2.58 ± 0.82 | 737 ± 234 | 7 | |||
1 | 0.11 ± 0.01 | Verbenol | 300 | 0.89 ± 0.13 | 809 ± 118 | 6 | |||
Human α1β2γ2 | HEK293 | Iabs [nA] | Iabs [nA] | ||||||
1 | 0.51 ± 0.15 | α-Phellandrene | 1000 | 0.83 ± 0.21 | 168 ± 42 | 3 | * | ||
1 | 0.29 ± 0.07 | β-Pinene | 1000 | 0.52 ± 0.16 | 179 ± 55 | 4 | * | ||
1 | 1.18 ± 0.58 | α-Pinene | 1000 | 1.37 ± 0.66 | 116 ± 56 | 3 | * | ||
1 | 0.23 ± 0.04 | Sabinene | 1000 | 0.36 ± 0.06 | 156 ± 26 | 6 | * | ||
1 | 1.14 ± 0.62 | α-Caryophyllene | 1000 | 1.34 ±0.66 | 117 ± 57 | 7 | * | ||
1 | 1.32 ± 0.61 | β-Caryophyllene | 1000 | 1.53 ± 0.69 | 115 ± 52 | 3 | * |