Table 1.

Current amplitudes of ionotropic GABA_ARs modulated by odor substances

Expressed subunits	Expression system	GABA [μM]	Iabs [μA]	Modulator	GABA + modulator [μM]	Iabs [μA]	Irel [% of 1 μM GABA]	n	Originally identified in Sideritis extract
Rat α1β2	Xenopus oocytes
		1	0.41 ± 0.07	α-Phellandrene	1000	0.46 ± 0.08	112 ± 19	3	*
		1	0.24 ± 0.06	β-Pinene	1000	0.35 ± 0.08	134 ± 31	7	*
		1	0.26 ± 0.05	Linalool	1000	1.23 ± 0.25	473 ± 96	4	*
		1	1.99 ± 0.64	1-Octen-3-ol	1000	6.40 ± 1.74	321 ± 87	4	*
		1	0.58 ± 0.13	Carveol	600	1.71 ± 0.26	294 ± 45	10
		1	0.31 ± 0.10	Pinocarveol	600	1.11 ± 0.32	358 ± 103	7
		1	0.30 ± 0.04	Isopulegol	600	1.25 ± 0.43	416 ± 143	8
		1	0.18 ± 0.09	Carvacrol	300	0.44 ± 0.22	414 ± 142	5	*
		1	0.55 ± 0.25	Myrtenol	300	2.55 ± 1.00	463 ± 181	7
		1	0.38 ± 0.16	Verbenol	300	1.00 ± 0.38	263 ± 99	7
		1	0.25 ± 0.08	α-Pinene	1000	0.35 ± 0.08	140 ± 32	7	*
		1	0.23 ± 0.05	Myrcene	1000	0.34 ± 0.06	147 ± 26	7	*
		1	0.22 ± 0.04	Caryophyllene oxide	1000	0.24 ± 0.04	109 ± 18	7	*
		1	0.052 ± 0.029	Sabinene	1000	0.057 ± 0.034	109 ± 65	4	*
		1	0.04 ± 0.02	β-Caryophyllene	1000	0.085 ± 0.04	212 ± 99	4	*
		1	0.09 ± 0.04	α-Terpeniol	1000	0.16 ± 0.06	177 ± 66	3	*
		1	0.51 ± 0.09	Cedrol	600	1.09 ± 0.18	213 ± 35	11
		1	0.53 ± 0.09	Nerolidol	600	0.73 ± 0.11	137 ± 21	11
		1	0.46 ± 0.28	2-Methyl-3-buten-2-ol	600	1.19 ± 0.28	258 ± 61	8
		1	0.59 ± 0.13	β-Citronellol	600	0.99 ± 0.18	167 ± 30	10
		1	0.26 ± 0.05	α-Santonin	600	0.57 ± 0.12	219 ± 46	3
		1	0.31 ± 0.09	Theaspiran	600	0.68 ± 0.15	219 ± 48	7
		1	0.84 ± 0.27	α-Thujone	600	0.52 ± 0.20	62 ± 24	3
		1	0.33 ± 0.06	Terpinolene	600	0.69 ± 0.16	209 ± 48	6
		1	0.37 ± 0.07	Myrtenal	600	0.89 ± 0.18	240 ± 48.5	8
		1	0.31 ± 0.02	Nootkatone	600	0.46 ± 0.06	148 ± 19	7
Human α1β2γ2	Xenopus oocytes
		1	0.79 ± 0.25	Linalool	300	1.69 ± 0.84	213 ± 105	10
		1	0.22 ± 0.05	1-Octen-3-ol	300	0.65 ± 0.11	295 ± 50	6
		1	0.13 ± 0.08	Carveol	300	0.59 ± 0.23	453 ± 176	8
		1	0.35 ± 0.08	Pinocarveol	300	1.67 ± 0.24	477 ± 68	8
		1	0.49 ± 0.13	Isopulegol	300	1.67 ± 0.035	340 ± 70	7
		1	1.72 ± 0.64	Carvacrol	300	3.86 ± 1.46	224 ± 85	6
		1	0.35 ± 0.12	Myrtenol	300	2.58 ± 0.82	737 ± 234	7
		1	0.11 ± 0.01	Verbenol	300	0.89 ± 0.13	809 ± 118	6
Human α1β2γ2	HEK293		Iabs [nA]			Iabs [nA]
		1	0.51 ± 0.15	α-Phellandrene	1000	0.83 ± 0.21	168 ± 42	3	*
		1	0.29 ± 0.07	β-Pinene	1000	0.52 ± 0.16	179 ± 55	4	*
		1	1.18 ± 0.58	α-Pinene	1000	1.37 ± 0.66	116 ± 56	3	*
		1	0.23 ± 0.04	Sabinene	1000	0.36 ± 0.06	156 ± 26	6	*
		1	1.14 ± 0.62	α-Caryophyllene	1000	1.34 ±0.66	117 ± 57	7	*
		1	1.32 ± 0.61	β-Caryophyllene	1000	1.53 ± 0.69	115 ± 52	3	*