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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Magn Reson Med. 2013 Jul 10;71(6):1959–1972. doi: 10.1002/mrm.24859

Table 1.

Model Simulation and Results (10 Trials Per Simulation)

SNRα-ATP
10
20
30
40
50
w/o noise
HLW used for simulations (Hz) 20 30 20 30 20 30 20 30 20 30 20 30
9.4 T HLW (Hz) 20.0 ± 0.7 29.5 ± 0.5 19.9 ± 0.3 29.7 ± 0.3 19.8 ± 0.1 30.0 ± 0.2 19.8 ± 0.2 29.9 ± 0.2 19.8 ± 0.1 29.9 ± 0.1 19.8 29.8
RX 2.66 ± 0.40 3.32 ± 1.14 3.01 ± 0.46 3.20 ± 0.77 3.11 ± 0.26 3.01 ± 0.38 3.02 ± 0.24 3.09 ± 0.26 3.04 ± 0.11 2.87 ± 0.22 3.00 2.99
[NAD+] (μmol/g) 0.37 ± 0.02 0.40 ± 0.05 0.39 ± 0.02 0.39 ± 0.02 0.39 ± 0.01 0.39 ± 0.01 0.39 ± 0.01 0.39 ± 0.01 0.39 ± 0.01 0.38 ± 0.01 0.39 0.39
[NADH] (μmol/g) 0.15 ± 0.02 0.13 ± 0.04 0.14 ± 0.01 0.13 ± 0.02 0.13 ± 0.01 0.13 ± 0.01 0.13 ± 0.01 0.13 ± 0.01 0.13 ± 0.00 0.14 ± 0.01 0.13 0.13
[NAD]total (μmol/g) 0.52 ± 0.02 0.53 ± 0.02 0.53 ± 0.01 0.52 ± 0.01 0.52 ± 0.01 0.52 ± 0.01 0.52 ± 0.01 0.52 ± 0.01 0.52 ± 0.00 0.52 ± 0.01 0.52 0.52
HLW used for simulations (Hz) 30 45 30 45 30 45 30 45 30 45 30 45
16.4 T HLW (Hz) 30.1 ± 0.5 44.9 ± 1.3 29.7 ± 0.4 44.9 ± 0.4 29.9 ± 0.3 45.0 ± 0.3 29.9 ± 0.2 45.0 ± 0.3 29.9 ± 0.1 45.0 ± 0.1 29.9 44.9
RX 3.45 ± 1.28 2.97 ± 0.99 3.19 ± 0.48 3.06 ± 0.51 2.84 ± 0.22 3.31 ± 0.40 3.02 ± 0.13 2.83 ± 0.25 3.02 ± 0.18 3.00 ± 0.19 2.97 2.96
[NAD+] (μmol/g) 0.33 ± 0.02 0.31 ± 0.03 0.33 ± 0.02 0.32 ± 0.02 0.32 ± 0.01 0.33 ± 0.02 0.32 ± 0.01 0.31 ± 0.01 0.32 ± 0.01 0.32 ± 0.01 0.32 0.32
[NADH] (μmol/g) 0.10 ± 0.03 0.11 ± 0.03 0.11 ± 0.01 0.11 ± 0.01 0.11 ± 0.01 0.10 ± 0.01 0.11 ± 0.00 0.11 ± 0.01 0.11 ± 0.01 0.11 ± 0.01 0.11 0.11
[NAD]total (μmol/g) 0.43 ± 0.02 0.43 ± 0.01 0.44 ± 0.01 0.43 ± 0.01 0.43 ± 0.01 0.43 ± 0.01 0.43 ± 0.01 0.43 ± 0.01 0.43 ± 0.00 0.42 ± 0.00 0.43 0.43