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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Eur J Prev Cardiol. 2014 Jul 29;23(1):50–58. doi: 10.1177/2047487314544046

Table 3.

Mediation of IS effect on first year change of gender standardized log Adipokines by Waist Circumference and BMI

a) waist circumference
IS Alone IS effect adjusted for
Waist Circumference
% of IS effect that is
mediated
IS vs. IP* p-value IS vs. IP* p-value
Leptin ng/ml −0.1939 <0.0001 −0.1645 <0.0001 15%
Adiponectin ug/ml 0.9652 <0.0001 0.9718 <0.0001 −0.68%
MCP-1 pg/ml −0.0435 0.22 −0.0403 0.28 7.4%
Leptin / Adiponectin Ratio −0.6756 <0.0001 −0.6579 <0.0001 2.6%
Leptin / BMI Ratio 0.0230 <0.0001 0.0161 <0.0001 30%
TNF-α pg/ml −0.0292 0.42 −0.0483 0.19 − 65%
IL-6 pg/ml −0.2092 <0.0001 −0.2124 <0.0001 −1.5%
CRP ug/ml −0.4127 <0.0001 −0.4182 <0.0001 −1.3%
b) BMI
IS Alone IS effect adjusted for
BMI
% of IS
effect
that is
mediated
IS vs. IP* p-value IS vs. IP* p-value
Leptin ng/ml −0.1939 <0.0001 −0.1179 0.0013 39%
Adiponectin ug/ml 0.9652 <0.0001 0.9792 <0.0001 −1.4%
MCP-1 pg/ml −0.0435 0.23 −0.0419 0.26 3.8%
Leptin / Adiponectin Ratio −0.6756 <0.0001 −0.6252 <0.0001 7.5%
Leptin / BMI Ratio 0.0230 <0.0001 0.0019 0.0059 92%
TNF-α pg/ml −0.0292 0.42 −0.0479 0.19 − 64%
IL-6 pg/ml −0.2092 <0.0001 −0.1988 <0.0001 5.0%
CRP ug/ml −0.4127 <0.0001 −0.4140 <0.0001 −0.33%
*

Beta coefficients from a linear regression model

Leptin is reported in pg/ml and adiponectin is reported in μg/ml, so their ratio is a multiple of 1000.