Table 3.
Mediation of IS effect on first year change of gender standardized log Adipokines by Waist Circumference and BMI
a) waist circumference | |||||
---|---|---|---|---|---|
IS Alone | IS effect adjusted for Waist Circumference |
% of IS effect that is mediated |
|||
IS vs. IP* | p-value | IS vs. IP* | p-value | ||
Leptin ng/ml | −0.1939 | <0.0001 | −0.1645 | <0.0001 | 15% |
Adiponectin ug/ml | 0.9652 | <0.0001 | 0.9718 | <0.0001 | −0.68% |
MCP-1 pg/ml | −0.0435 | 0.22 | −0.0403 | 0.28 | 7.4% |
Leptin / Adiponectin Ratio† | −0.6756 | <0.0001 | −0.6579 | <0.0001 | 2.6% |
Leptin / BMI Ratio | 0.0230 | <0.0001 | 0.0161 | <0.0001 | 30% |
TNF-α pg/ml | −0.0292 | 0.42 | −0.0483 | 0.19 | − 65% |
IL-6 pg/ml | −0.2092 | <0.0001 | −0.2124 | <0.0001 | −1.5% |
CRP ug/ml | −0.4127 | <0.0001 | −0.4182 | <0.0001 | −1.3% |
b) BMI | |||||
---|---|---|---|---|---|
IS Alone | IS effect adjusted for BMI |
% of IS effect that is mediated |
|||
IS vs. IP* | p-value | IS vs. IP* | p-value | ||
Leptin ng/ml | −0.1939 | <0.0001 | −0.1179 | 0.0013 | 39% |
Adiponectin ug/ml | 0.9652 | <0.0001 | 0.9792 | <0.0001 | −1.4% |
MCP-1 pg/ml | −0.0435 | 0.23 | −0.0419 | 0.26 | 3.8% |
Leptin / Adiponectin Ratio† | −0.6756 | <0.0001 | −0.6252 | <0.0001 | 7.5% |
Leptin / BMI Ratio | 0.0230 | <0.0001 | 0.0019 | 0.0059 | 92% |
TNF-α pg/ml | −0.0292 | 0.42 | −0.0479 | 0.19 | − 64% |
IL-6 pg/ml | −0.2092 | <0.0001 | −0.1988 | <0.0001 | 5.0% |
CRP ug/ml | −0.4127 | <0.0001 | −0.4140 | <0.0001 | −0.33% |
Beta coefficients from a linear regression model
Leptin is reported in pg/ml and adiponectin is reported in μg/ml, so their ratio is a multiple of 1000.