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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: J Neurochem. 2014 Oct 18;133(2):266–272. doi: 10.1111/jnc.12960

Fig. 1. Proposed transcription-based mechanism of tau and CDK5 downregulation by tolfenamic acid.

Fig. 1

Tolfenamic acid induces the degradation of the transcription factor Sp1 (Abdelrahim et al. 2006, Adwan et al. 2011, Subaiea et al. 2013), which reduces the transcription of its target genes such as tau and CDK5 activator, resulting in a decrease in the total levels of tau as well as the pathogenic phosphorylated tau species.