Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
BoNT-A molecule with heavy chain, light chain and disulphide connection. The heavy chain (100 kD) is important for docking and endocytosis of BoNT-A in the nerve end terminal. In the nerve end terminal, the light chain (50 kD) cleaves SNAP-25 protein, which is essential in the fusion of acetylcholine vesicles with the nerve end membrane [17].
