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. 2015 Feb 19;5:5. doi: 10.1186/s13550-015-0083-5

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© van Uhm et al.; licensee Springer. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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The results of the rat bladder strip in vitro model. Rat bladder strip mounted in two parallel organ baths and incubated in ¹²⁵I-BoNT-A (A) showing no inhibition of contraction force induced by electrical field stimulation (EFS) in time and unlabelled BoNT-A (B) showing inhibition of contraction force induced by EFS in time. Both strips are simultaneously stimulated by potassium chloride (KCl; three times), carbachol (CCh; three times), EFS (repetitive) and CCh (three times). The CCh-induced strip contraction before and after incubation is a viability check of the strip during the experiment.