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Results of iodination of cetuximab with increasing amount of 125 I
| Cetuximab (μg) | 125 I (MBq) | Labelling efficiency (%) | Radiochemical purity (%) | Immunoreactivity (%) | 125 I/mAb molar ratio a |
|---|---|---|---|---|---|
| 50 | 15.0 | 71.4 | 99.1 | 95.2 | 0.40 |
| 50 | 48.4 | 75.2 | 99.7 | ND | 1.36 |
| 50 | 73.1 | 81.9 | 99.3 | 96.9 | 2.29 |
| 50 | 112.2 | 72.9 | 99.8 | ND | 3.05 |
| 50 | 150.0 | 77.0 | 99.4 | 96.8 | 4.30 |
Conditions: 2.5 μg IODOGEN, 250 μL reaction volume and 90-s reaction time. ND = not determined.
a100 MBq 125I corresponds with 1.24 nmol I atoms.
