Table 3.

Rare-Variant Analysis in GENOA Affected Sibships

Outcome	Gene	p Value (Weighted)	p Value (Unweighted)
Hypertension	GOSR2	0.865	0.674
	GUCY1A3	0.421	0.513
	PLEKHG1	0.378	0.387
	SH2B3	0.970	0.932
	ULK4	0.834	0.578
Obesity	ADCY3	0.799	0.671
	BDNF	0.520	0.585
	FTO	0.597	0.346
	GNPDA2	0.636	0.451
	KLHL32	0.442	0.254
	MAP2K5	0.890	0.670
	MC4R	0.142	0.191
	NFE2L3	0.919	0.872
	NRXN3	0.0024	0.043
	SEC16B	0.739	0.632
	SH2B1	0.393	0.305
	QPCTL	0.382	0.232

p value for Y_Burden based on 1-sided test. Weights based on ${\left(\sqrt{MAF\left(1-MAF\right)}\right)}^{-1}$.