Figure 3.

PET images and TACs of [ ¹¹ C]erlotinib (top) and [ ¹⁸ F]afatinib (bottom). Circle indicates tumor position and arrow indicates reference tissue. [¹¹C]erlotinib images summed from 60 to 90 min, [¹⁸F]afatinib images from 90 to 120 min. TACs are averaged over three animals. Mutations: A549 (wild type), H1975 (L858R/T790M), and HCC827 (exon 19 deletion). Tumor and background were manually outlined on the basis of an additional [¹⁸F]FDG scan, which was performed directly after the TKI-PET scan was finished.