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. 2015 Mar 20;5:14. doi: 10.1186/s13550-015-0088-0

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© Slobbe et al.; licensee Springer. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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Scheme 2 — Radiosynthesis of [ ¹⁸ F]6 and subsequent condensation towards [ ¹⁸ F]afatinib. MeCN, acetonitrile; MeOH, methanol; DBU, 1,8-diazabicyclo[5.4.0]undec-7-een; NMP, N-methylpyrrolidone.