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. Author manuscript; available in PMC: 2015 Apr 4.
Published in final edited form as: J Cell Physiol. 2009 Jun;219(3):525–528. doi: 10.1002/jcp.21749

Fig. 2.

Fig. 2

Higher-order arrangements of the chromatin fiber could enable the assembly of silenced chromatin. A: A loop could bring multiple nucleosomes into close proximity to the Sir complex (gray balls) at a silencer. Three silencer binding proteins, the origin recognition complex (ORC), Rap1 (R), and Abf1 (A), recruit the Sir proteins to the silencer. Once recruited, Sir2p could deacetylate any nucleosome in close proximity to the silencer (arrows). B:A compact chromatin fiber, such as the 30 nm fiber, could also result in multiple nucleosomes being close to Sir2p at the silencer.