Table 6.
Summary of significant biomarkers by category
| Diagnosis (n = 16) |
Significant studies/total studies | Severity of hip OA (n = 16) |
Significant studies/total studies | Prognosis (n = 6) |
Significant studies/total studies | Prearthritic hip disease (n = 3) |
Significant studies/total studies |
|---|---|---|---|---|---|---|---|
| uCTX-II | 3/3 | sCRP | 2/4 | sCOMP | 3/3 | sCOMP | 2/2 |
| sCRP | 2/3 | uCTX-II | 2/2 | s25-OH Vit D | 2/2 | sCRP | 1/1 |
| sTGF-B1 | 1/2 | sCOMP | 1/4 | sNTX | 1/2 | sfFAC | 1/1 |
| uHelix-II | 1/1 | sDCOMP | 1/1 | uCTX-II | 1/1 | ||
| uDPD | 1/2 | uHelix-II | 1/1 | sTIMP-1 | 1/1 | ||
| uPYD | 1/1 | sIL-6 | 1/2 | sVCAM-1 | 1/1 | ||
| sMMP-3 | 1/1 | sIL-1B | 1/1 | ||||
| sYKL-40 | 1/1 | sIL-8 | 1/1 | ||||
| sAAT | 1/1 | sBSP | 1/1 | ||||
| sCAT-D | 1/1 | sfC6S/C4S | 1/1 | ||||
| sIL-10 | 1/1 | sCP-II | 1/1 | ||||
| sIL-12p70 | 1/1 | sICTP | 1/1 | ||||
| sKS | 1/1 | sfL2-KS | 1/1 | ||||
| sMMP-9 | 1/1 | sLeptin | 1/1 | ||||
| sNO | 1/1 | sTNF-α | 1/1 | ||||
| ssIL4-R | 1/1 | sfTRACP-5B | 1/1 |
OA = osteoarthritis; s25-OHVitd = serum25-hydroxyVitaminD; sAAT = serumalpha-1antitrypsin; sBSP = serumbonesialoprotein; sCAT-D = serumcathepsinD; sCOMP = serumcartilageoligomericprotein; sCP-II = serumC-propeptide; sCRP = serumC-reactiveprotein; sDCOMP = serumdeaminatedcartilageoligomericprotein; sICTP = serumcrosslinkingC-terminaltelopeptide; sIL = seruminterleukin; sIL-12p70 = seruminterleukin12p70; ssIL4-R = serumsolubleIL-4receptor; sKS = serumkeratansulfate; sLeptin = serumleptin; sMMP3 = serummatrixmetalloproteinase-3; sMMP-9 = serummatrixmetalloproteinase-9; sNO = serumnitrousoxide; sNTX = serumN-terminaltelopeptide; sTGF-B1 = serumtransforminggrowthfactorβ1; sTIMP-1 = serumTIMPmetalloproteinaseinhibitor1; sTNF-α = serumtumornecrosisfactor-alpha; sVCAM-1 = serumvascularcelladhesionmolecule1; sYKL-40 = serumhumancartilageglycoprotein39; sfC6S/C4S = synovialfluidchondroitin-6-sulfatetochondroitin-4-sulfateratio; sfFAC = serumfibronectin-aggrecancomplex; sfL2-KS = serumB-galactosyl-(1-4)-6-0-sulfo-N-acetylglucosamine(L2fragmentofkeratansulfate); sfTRACP-5B = serumtartrate-resistantacidphosphatase5b; uCTX-II = urinarytypeIIcollagentelopeptide; uDPD = urinarydeoxypyridinoline; uHelix-II = urinarytypeIIcollagenhelicaltelopeptide; uPYD = urinarypyridinoline.