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. Author manuscript; available in PMC: 2015 Apr 4.
Published in final edited form as: Brain Dev. 2011 Jun 12;33(9):796–805. doi: 10.1016/j.braindev.2011.04.013

Figure 1. GABA degradation pathway.

Figure 1

GABA is normally converted via GABA-transaminase to succinate semialdhyde, which is then broken down to succinic acid by succinate semialdehyde dehydrogenase (SSADH). In the absence of SSADH, succinate semialdehyde is converted to GHB rather than succinic acid, and this leads to a build up of both GHB and GABA in the brain.