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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Neurotox Res. 2015 Mar 1;27(4):368–383. doi: 10.1007/s12640-015-9521-4

Figure 4.

Figure 4

Time course of increasedprotein levels of γH2AX and p-p53ser15in fibroblast (A, B, C and D) and SH-SY5Y (E, F, G and H) cells after CPT treatment. Cells were treated with CPT (10 μM) for 15, 30, 60, 90 and 120 min, then western blots were performed. A, B, E and F showed autoradiographsof γH2AX and p-p53ser15proteins obtained by western blotting. The graphic data, shown in C, D, G and H, represent a quantitative analysis of protein levels of γH2AX and p-p53ser15, which were normalized to β-actin. These graphic data represent averages obtained from 4 separate experiments. *p<0.01, ** p<0.0001, compared to the group of 0 min; # p<0.05, ## p<0.0001, compared to the group of 120 min.