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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Neurotox Res. 2015 Mar 1;27(4):368–383. doi: 10.1007/s12640-015-9521-4

Figure 8.

Figure 8

CPT-induced DNA damage as determined by the comet assay in fibroblast and SH-SY5Ycells. The cells were exposed to CPT (10 μM) for 2 h, then CPT was washed away, cells continued to grow in media without CPT for 24 h, 48 h and 72 h. The cells were processed for neutral or alkaline comet assays. Images were taken with 10× magnification. A: After CPT treatment, both neutral and alkaline comet assay detected comet tails in fibroblast cells. Comet tails were shorted or disappeared at 24 h. B: After CPT treatment, only alkaline comet assay detected comet tails in SH-SY5Y cells. Comet tails were shorted or disappeared within 72 h. See Figs. 5 and 6 for abbreviations.