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. Author manuscript; available in PMC: 2016 Feb 15.
Published in final edited form as: Int J Cardiol. 2014 Oct 24;181:180–184. doi: 10.1016/j.ijcard.2014.10.148

Table 1.

Gab1 as a critical regulator of postnatal angiogenesis.

Studies by Animal Model In vitro model Signaling pathways involved
Zhao et al [41] Gab1-ecKO+HLI HGF SHP2-ERK, PI3K-Akt
Shioyama et al [43] Gab1-ecKO+HLI;
Gab2-KO+HLI;
VEGF, HGF gene
transfer		 HGF; VEGF;
FGF2		 SHP2-ERK1/2-Egr1, SHP2-ERK5-KLF2;
PI3K-Akt
Lu et al [42] Gab1-ecKO+HLI VEGF SHP2-PKA-eNOS

Abbreviations: Egr1, early growth response 1; eNOS, endothelial nitric oxide synthase; FGF2, fibroblast growth factor-2; Gab1-ecK0, endothelial cell-specific Gab1 knockout; HLI, hindlimb ischemia; HGF, hepatocyte growth factor; KLF2, kruppel-like factor 2; VEGF, vascular endothelial growth factor.