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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Prostaglandins Other Lipid Mediat. 2014 Dec 17;0:124–130. doi: 10.1016/j.prostaglandins.2014.12.001

Table 1. Vascular Reactivity.

Effect of DHT on WT and Agt+/− mice vascular reactivity in response to phenylephrine-induced constriction (EC50 (µM)) (A) and % relaxation to acetylcholine at 5 × 10−6 M Acetylcholine (B).

A
EC50 (µM) to
Phenylephrine		 Placebo DHT DHT +
20-HEDE		 DHT+
Lisinopril
WT Mice 0.50 ± 0.06 0.12 ± 0.03 * 0.60 ± 0.25 # 0.37 ± 0.09*#
Agt+/− Mice 0.56 ± 0.16 0.22 ± 0.06* † 0.53 ± 0.14 # 0.28 ± 0.04*
B
% Relaxation
(5 × 10−6 M
Acetylcholine)
 Placebo DHT DHT +
20-HEDE		 DHT+
Lisinopril
DHT+ 20-HEDE
+ 20-HETE
(ex vivo)
WT Mice 90 ± 2 26 ± 6* 74 ± 9 # 70 ± 9 # 34 ± 13**
Agt+/− Mice 87 ± 2 77 ± 4 71 ± 8 79 ± 9 48 ± 7**

Results are mean ±SE (n=3–4).

*

p<0.05 vs Placebo-treated mice,

#

p<0.05 vs DHT-treated mice,

†

p<0.05 vs DHT-treated WT mice,

**

p<0.05 vs DHT+20-HEDE-treated mice.