Table 1.
Authors | Country of study | Patients | Cycle Type | Ovarian stimulation | Progesterone Type | Randomization Groups (by initiation of P) | P regimen | Ovulation triggering |
---|---|---|---|---|---|---|---|---|
Sohn et al. 1999 | USA | General IVF-no exclusion reported | Fresh augolous IVF | Long GnRH agonist with hMG and/or FSH. | Progesterone 12.5 mg IM then 25mg IM Progesterone 25 mg IM | Group A: 12.5mg dose 12 hours before OR and the evening of OR then 25mg dose Group B: evening of OR |
Daily through first trimester | hCG (amount not stated) |
Williams et al. 2001 | USA | General IVF-no exclusion reported | Fresh augolous IVF | Long GnRH agonist, luteal GnRH agonist stop, or GnRH agonist micro-dose flare. rFSH 150–450 IU daily. | Prometrium, 200mg vaginally TID | Group A: morning of the 3rd day after OR Group B: morning of the 6th day after OR |
Daily until 10 weeks gestation | 10,000 units hCG |
Fanchin et al. 2001 | France | General IVF-excluded patients with abnormal uterus | Fresh augolous IVF | Long GnRH agonist. rFSH 225 IU FSH for 5 days, then flexible dosing | Crinone 8% vaginally | Group A: immediately after OR Group B: evening of ET |
Daily until pregnancy ruled out | 10,000 units hCG |
Baruffi et al. 2003 | Brazil | General IVF-no exclusion reported | Fresh augolous IVF | Long GnRH agonist. rFSH 150–300 IU daily. | Utrogestan, 400 mg vaginally | Group A: evening of ORGroup B: evening of ET | Not stated | 5,000-10,000 units hCG |
Mochtar et al. 2006 | Netherlands | General IVF-no exclusion reported | Fresh augolous IVF | Long GnRH agonist. rFSH, hMG, or hpFSH. | Micronized progesterone 400 mg vaginally BID | Group A: evening of hCG administration Group B: evening after OR Group C: evening 3 days after OR |
Daily until 18 days post OR | 10,000 units hCG |