TABLE 1. Changes of ipsilateral QEEG values evoked by amobarbital or methohexital injections during Wada testing. (Values are average ± s.e.m, n=26).
| Drug | Delta | Theta | Alpha | Beta | aEEG | ADR | BDR | SEF90 | |
|---|---|---|---|---|---|---|---|---|---|
|
Peak
Change * |
Amo- barbital |
2.34 ±0.11 |
1.83 ±0.09 |
1.67 ±0.12 |
1.69 ±0.20 |
1.52 ±0.12 |
−1.66 ±0.14 |
−1.91 ±0.16 |
−6.08 ±0.88 |
|
| |||||||||
| Metho- hexital |
1.92 ±0.13 |
1.97 ±0.15 |
1.99 ±0.14 |
2.20 ±0.19 |
1.93 ±0.18 |
−1.19 ±0.12 |
−1.38 ±0.13 |
−4.83 ±0.85 |
|
|
| |||||||||
|
Time to
peak change (s) |
Amo- barbital |
29.69 ±4.48 |
44.23 ±12.39 |
164.00 ±18.69 |
97.54 ±11.27 |
46.92 ±12.07 |
22.15 ±3.01 |
30.62 ±6.17 |
55.54 ±13.70 |
|
| |||||||||
| Metho- hexital |
38.46 ±5.40 |
91.54 ±11.04 |
141.08 ±14.50 |
99.08 ±10.13 |
83.08 ±10.62 |
20.77 ±3.08 |
33.54 ±10.00 |
66.00 ±15.73 |
|
|
| |||||||||
|
10-90%
Decay Time (s) |
Amo- barbital |
253.22 ±18.14 |
312.46 ±23.63 |
318.16 ±20.77 |
329.31 ±19.68 |
402.98 ±27.80 |
87.32 ±9.71 |
94.28 ±14.49 |
113.44 ±23.58 |
|
| |||||||||
| Metho- hexital |
149.95 ±8.75 |
198.70 ±13.84 |
253.02 ±16.02 |
274.66 ±18.84 |
227.75 ±17.35 |
49.65 ±9.90 |
39.09 ±8.83 |
56.42 ±11.93 |
|
|
| |||||||||
| SNR | Amo- barbital |
5.63 ±0.46 |
6.02 ±0.47 |
5.80 ±0.55 |
5.76 ±0.97 |
11.02 ±1.13 |
4.49 ±0.57 |
4.95 ±0.57 |
2.50 ±0.45 |
|
| |||||||||
| Metho- hexital |
4.92 ±0.37 |
7.17 ±0.63 |
11.06 ±1.41 |
8.69 ±1.59 |
21.60 ±2.40 |
3.73 ±0.29 |
3.49 ±0.31 |
2.03 ±0.34 |
|
*
Peak Change: For Delta, Theta, Alpha, Beta, ADR, and BDR, values are ratio of logarithms of peak values versus control values. Negative peak changes represent troughs. For aEEG, values are the ratio of peak value divided by control values. For SEF90, values are decreases in Hz compared to controls. All control values were median values calculated from recordings 0-5 min before injections.