Table 3.

Statistical significance (T-score) of clusters showing group differences in their functional connectivity between the seed and the cluster location in MNI space (X, Y, Z coordinates in mm)

			k	BA/nucleus	X	Y	Z	T-score
CAUDATE
REST	PD>CTL	Thalamus, claustrum, insula, cingulate cortex	905	13, 29, 30, lateral dorsal and posterior thalamic nuclei	−12	−22	18	5.41
					−26	−24	22	5.36
					16	−20	20	4.11
	CTL>PD	Premotor, motor, and somatosensory cortices (pre- and postentral gyri)	830	2, 3, 4, 6	52	−14	38	4.95
					34	−12	38	4.80
					38	−28	40	3.42
TASK	PD>CTL1	Anterior prefrontal and orbitofrontal cortices	52	10, 11	−12	66	−16
	CTL>PD	Supramarginal gyrus, temporoparietal junction, angular and superior temporal gyrus, insula	1166	13, 22, 40, 39, 42	−54	−42	18	5.94
					−50	−38	52	4.81
					−60	−42	42	4.63
PUTAMEN
REST	PD>CTL	no suprathrehold voxels
	CTL>PD	Anterior prefrontal cortex	187	10	−32	64	4	6.67a
TASK	PD≠CTL	no suprathreshold voxels
GLOBUS PALLIDUS
REST	PD>CTL	no suprathreshold voxels
	CTL>PD1	Visual association cortex	47	18, 19	−38	−84	−2	5.71
		Cerebellum	22	IX	−30	−52	−48	4.61
TASK	PD>CTL	no suprathrehold voxels
	CTL>PD	Inferior prefrontal gyrus, subgenual cortex, temporopolar area	682	25, 38, 47	18	16	−16	4.31
					10	2	−4	4.19
					6	8	−14	4.03
THALAMUS
REST	PD>CTL	Posterior cingulate cortex, visual association areas	881	18, 30	−26	−68	2	4.97
				1	−32	−88	−2	4.95
					−34	−94	−18	3.97
		Precuneus, inferior parietal lobe	622b	7, 40	−18	−76	42	4.70
					−6	−86	44	4.51
					−32	−54	42	4.12
	CTL>PD	Inferior frontal triangular and dorsolateral prefrontal cortices	754	9, 44, 46, 48	38	24	26	5.05
					36	30	40	3.90
		Cerebellum	712	VIIb, VIII, IX	−6	−76	−48	5.00
					−24	−50	−50	4.06
					−2	−60	−42	3.49
		Cerebellum	721	Crus2, Crus1	24	−84	−34	4.47
					38	−80	−42	4.16
					16	−82	−32	4.07
TASK	PD>CTL	Parahippocampal gyrus, hypothalamus, subgenual cortex	547c	25, 28, 34	−10	2	−14	6.28
					6	−2	−16	4.01
					12	4	−14	3.64
		Precuneus, angular and supramarginal gyri, superior and inferior parietal lobe, dorsal posterior cingulate cortex, extrastriate areas	2281	7, 18, 19, 30, 31, 39, 40	−22	−60	44	4.31
					−20	−72	46	4.19
					−6	−60	38	3.95
	CTL>PD	no suprathreshold voxels

For analysis group differences (PD≠CTL), cluster extent threshold at p_{FWE corrected} = 0.05, peak at T(1,20)min=2.53; k = number of synchronously activated brain voxels.

^atrend for peak p_{FWE corrected} >0.05 <0.1;

^bcluster extent p_{FDR corrected} < 0.05;

^ctrend for cluster extent p_{FDR corrected} >0.05 <0.1;

¹peak p=0.001; T(1,20) min = 3.55, k=20.

Abbreviations: Parkinson Disease patients (PD), control participants (CTL), Brodmann area (BA)