Table 4.
Statistical significance (T-score) of clusters showing group-by-condition interactions in their connectivity between the seed and the cluster location in MNI space (X, Y, Z coordinates in mm)
| A) Analysis threshold: peak at T(1,20) min = 2.53; extent at pFWE corrected = 0.05 | |||||||
|---|---|---|---|---|---|---|---|
| k | BA/nucleus | X | Y | Z | T-score | ||
| GLOBUS PALLIDUS – right | |||||||
| T > R CTL>PD | Inferior prefrontal and orbitofrontal gyri, temporopolar area, middle temporal gyrus, subgenual, dorsal anterior cingulate and anterior entorhinal cortices | 2447 | 10, 11, 21, 25, 32, 34, 38, 47 | −2 | 16 | −20 | 6.75 |
| 24 | 24 | −18 | 5.72 | ||||
| 16 | 20 | −18 | 4.96 | ||||
| Fusiform, extrastriate, parahippocampal and inferior temporal gyri, perirhinal and piriform cortices | 477a | 19, 20, 27, 35, 36, 37 | 32 | −38 | −10 | 5.17 | |
| 26 | −54 | −4 | 4.24 | ||||
| 26 | −32 | −16 | 3.03 | ||||
|
| |||||||
| B) Analysis threshold: peak p=0.001, T(1,20) min = 3.55, k min = 60 | |||||||
| CAUDATE – left | |||||||
| T > R PD>CTL | Precuneus, superior parietal lobe | 66 | 7 | 0 | −68 | 36 | 4.41 |
|
| |||||||
| PUTAMEN – left | |||||||
| T > R CTL>PD | Dorsal posterior cingulate cortex | 60 | 31 | −22 | −44 | 36 | 5.58 |
| – right | |||||||
| T > R PD>CTL | Motor and premotor cortices | 80 | 4, 6 | 26 | −22 | 56 | 5.02 |
|
| |||||||
| THALAMUS – left | |||||||
| T > R CTL>PD | Cerebellum | 61 | Crus2, declive | −8 | −72 | −24 | 5.31 |
extent at pFDR corrected < 0.05
Abbreviations: Parkinson Disease patients (PD), control participants (CTL), Task (T), Rest (R), Brodmann area (BA).